PowerShape 2015 Crack [WORK]
Throughout the African American community, individuals and organizations ranging from churches to schools to drug treatment centers are fighting the widespread use of crack cocaine. To put that fight in a larger cultural context, Doin' Drugs explores historical patterns of alcohol and drug use from pre-slavery Africa to present-day urban America.
PowerShape 2015 crack
William Henry James and Stephen Lloyd Johnson document the role of alcohol and other drugs in traditional African cultures, among African slaves before the American Civil War, and in contemporary African American society, which has experienced the epidemics of marijuana, heroin, crack cocaine, and gangs since the beginning of this century. The authors zero in on the interplay of addiction and race to uncover the social and psychological factors that underlie addiction.
Induction heating technique is an innovative asphalt pavement maintenance method that is applied to inductive asphalt concrete mixes in order to prevent the formation of macro-cracks by increasing locally the temperature of asphalt. The development of asphalt mixes with improved electrical and thermal properties is crucial in terms of producing induction healed mixes. This paper studies the induction healing capacity of asphalt mixes without aggregates as the part of asphalt concrete where inductive particles are dispersed notably contributing to the final response of asphalt pavements. Special attention was given to the characterization of inductive asphalt mixes using experimental techniques and numerical methods. The research reported in this paper is divided into two parts. In the first part, the impact of iron powder as filler-sized inductive particle on the rheological performance of asphalt-filler systems was studied. The mechanical response, the induction heating and healing capacity of asphalt mortar by adding iron powder and steel fibers was evaluated as well. In the second part, the utilization of advanced finite-element analyses for the assessment of the induction heating potential of inductive asphalt mortar with steel fibers are presented. The influential factors of induction mechanism in asphalt mixes are also described. The experimental and numerical findings of this research provided an optimization method for the design of induction healed asphalt concrete mixes and the development of necessary equipment that will enable the implementation of induction technology for healing of asphalt concrete mixes.
Asphalt concrete mixes are the most common types of pavement surface materials applied in transportation infrastructure and consist of asphalt binder, aggregate particles and air voids. These mixes are temperature-dependent materials with a self-healing capability because they can restore stiffness and strength [1-5]. Nowadays, it is known that asphalt concrete mixes should be considered as mixes of mortar-coated aggregates rather than binder-coated aggregates in terms of developing asphalt pavements with enhanced durability. In 2014, the European asphalt industry (EU27) produced about 280 million tonnes of asphalt and invested about 80 billion [euro] per year in pavement construction resulting increased energy consumption and C[O.sub.2] emissions during various asphalt production, construction and maintenance processes . The importance of reducing C[O.sub.2] emissions by developing new, last longer asphalt mixes and to enhance road safety by providing high quality road network is crucial for fulfilling the European objective for sustainable development. Within this framework, the necessity of solving construction and rehabilitation issues of pavement structures has led industry to focus on development of alternative novel state-of-the-art techniques. Regarding asphalt pavement maintenance, among others [7,8] healing of asphalt micro-cracks using the induction technique has been approved as a very promising method to prolong the service life of asphalt pavements [9-13].
During remodelling of pulmonary artery, marked proliferation of pulmonary artery smooth muscle cells (PASMCs) occurs, which contributes to pulmonary hypertension. Thromboxane A2 (TxA2) has been shown to produce pulmonary hypertension. The present study investigates the inhibitory effect of epigallocatechin-3-gallate (EGCG) on the TxA2 mimetic, U46619-induced proliferation of PASMCs. U46619 at a concentration of 10 nM induces maximum proliferation of bovine PASMCs. Both pharmacological and genetic inhibitors of p(38)MAPK, NF-κB and MMP-2 significantly inhibit U46619-induced cell proliferation. EGCG markedly abrogate U46619-induced p(38)MAPK phosphorylation, NF-κB activation, proMMP-2 expression and activation, and also the cell proliferation. U46619 causes an increase in the activation of sphingomyelinase (SMase) and sphingosine kinase (SPHK) and also increase sphingosine 1 phosphate (S1P) level. U46619 also induces phosphorylation of ERK1/2, which phosphorylates SPHK leading to an increase in S1P level. Both pharmacological and genetic inhibitors of SMase and SPHK markedly inhibit U46619-induced cell proliferation. Additionally, pharmacological and genetic inhibitors of MMP-2 markedly abrogate U46619-induced SMase activity and S1P level. EGCG markedly inhibit U46619-induced SMase activity, ERK1/2 and SPHK phosphorylation and S1P level in the cells. Overall, Sphingomyeline-Ceramide-Sphingosine-1-phosphate (Spm-Cer-S1P) signalling axis plays an important role in MMP-2 mediated U46619-induced proliferation of PASMCs. Importantly, EGCG inhibits U46619 induced increase in MMP-2 activation by modulating p(38)MAPK-NFκB pathway and subsequently prevents the cell proliferation. Copyright 2015 John Wiley & Sons, Ltd.
We investigate an extension of mimetic gravity in which mimetic matter is nonminimally coupled to the Ricci scalar. We derive the background field equations and show that, as the minimal case, the nonminimal mimetic matter can behave as dark matter or dark energy. By adopting some well-known potentials, we study the dynamics of the scale factor and the equation of state parameter in detail. As the effective mimetic dark energy, this model explains the late time cosmic acceleration and its equation of state parameter crosses the phantom divide. We extend our analysis to the dynamical system approach and the phase space trajectories of the model. We obtain an attractor line which corresponds to the late time cosmic acceleration. By comparing this nonminimal mimetic matter scenario with observational data for the LCDM, we show that the confidence levels of this model overlap with those of Planck 2015 TT, TE, EE + Low P + Lensing + BAO data in the LCDM model.
Age-associated degeneration in the central auditory system, which is defined as central presbycusis, can impair sound localization and speech perception. Research has shown that oxidative stress plays a central role in the pathological process of central presbycusis. Thioredoxin 2 (Trx2), one member of thioredoxin family, plays a key role in regulating the homeostasis of cellular reactive oxygen species and anti-apoptosis. The purpose of this study was to explore the association between Trx2 and the phenotype of central presbycusis using a mimetic aging animal model induced by long-term exposure to d-galactose (d-Gal). We also explored changes in thioredoxin-interacting protein (TXNIP), apoptosis signal regulating kinase 1 (ASK1) and phosphorylated ASK1 (p-ASK1) expression, as well as the Trx2-TXNIP/Trx2-ASK1 binding complex in the auditory cortex of mimetic aging rats. Our results demonstrate that, compared with control groups, the levels of Trx2 and Trx2-ASK1 binding complex were significantly reduced, whereas TXNIP, ASK1 p-ASK1 expression, and Trx2-TXNIP binding complex were significantly increased in the auditory cortex of the mimetic aging groups. Our results indicated that changes in Trx2 and the TXNIP-Trx2-ASK1 signal pathway may participate in the pathogenesis of central presbycusis. 2015 FEBS.
Bcl-2 proteins are key determinants in the life-death balance. In recent years, proteins in this family have been identified as drug targets in the design of new anti-tumor therapies. Advances in the knowledge of the mechanism of action of anti-apoptotic and pro-apoptotic members of the Bcl-2 family have enabled the development of the so-called 'BH3 mimetics'. These compounds act by inhibiting anti-apoptotic proteins of the family, imitating the function of the BH3-only subset of pro-apoptotic members. Combinations of BH3-mimetics with anti-tumor drugs are being evaluated in both preclinical models and clinical trials. Recent advances in these approaches will be reviewed. Copyright 2015 Elsevier Ltd. All rights reserved.
French historian and literary critic René Girard (1923-2015), most widely known for the concepts of mimetic desire and scapegoating, also engaged in the discussion of the surge of eating disorders in his 1996 essay Eating Disorders and Mimetic Desire. This article explores Girard's ideas on the mimetic nature and origin of eating disorders from a clinical psychiatric perspective and contextualizes them within the field of eating disorders research as well as in relation to broader psychological, sociological and anthropological models of social comparison and non-consumption. Three main themes in Girard's thinking on the topic of eating disorders are identified and explored: the 'end of prohibitions' as a driving force in the emergence of eating disorders, eating disorders as a phenomenon specific to modernity, and the significance of 'conspicuous non-consumption' in the emergence of eating disorders. 350c69d7ab